Selegiline 

Traditional drugs Selegiline(Sinemet, Nakoma, Madopar, Eldepryl 5mg) can be replaced by long-acting analogues (Sinemet CR, Madopar HBS, generic Eldepryl).

For slow-onset effect of the drug is recommended for 40 minutes before eating or using bystrovsasyvayuschihsya levodopa dosage forms (eg Madopar dispersible tablets).

At the peak dose dyskinesias should consider reducing the single dose of levodopa and withdrawal Selegiline with simultaneous recovery possible while reducing the effectiveness of treatment assignment or increasing doses of dopamine agonist or amantadine. In severe cases, you can assign the low-dose atypical antipsychotic, such as clozapine (leponeks) or olanzapine (Zyprexa).

In the two-phase dyskinesias should not be prescribed long-acting drugs, should increase the single dose and reduce the number of devices or drugs levodopa order Eldepryl.

In a sudden stop taking anti parkinson funds, a sharp decrease in their dose or malabsorption (due to gastro-intestinal tract) can develop akinetic crisis-catching of the patient to bed, and often leads to severe dysarthria and dysphagia. It is a medical emergency that requires, first and foremost, to maintain vital functions, fluid and electrolyte balance, adequate nutrition, prevention of deep vein thrombosis leg, pneumonia, pressure sores. If the crisis - the result of the abolition of Parkinson's Eldepryl, it should be reappointed, but in a slightly lower dose, then increase the dose to the former within 1-2 days. As an additional means to use / drip amantadine sulphate (PK-Merz, 200 mg 1-3 times a day). With the sudden cancellation or a rapid decrease in dose of levodopa may develop as neuroleptic malignant syndrome.